SS-31
Phase 3aka Elamipretide, MTP-131
Mitochondria-targeting peptide in phase 3 for rare mitochondrial disease.
Mechanism
A tetrapeptide that binds cardiolipin in the inner mitochondrial membrane, basically trying to fix the wiring so the mitochondria make energy properly again. One of the few here in serious late-stage trials.
Regulatory & Safety Status
Investigational (Stealth BioTherapeutics), late-stage trials for rare mitochondrial conditions. Not approved.
Research
Targeting Mitochondria in MASLD: Comparative Evaluation of MitoQ and SS-31 (Elamipretide) in Aged Female Mice under Nutritional Stress
Reactive oxygen species and antioxidant strategies in human sperm cryodamage
Mitochondrial-targeted SS-31 peptide attenuates radiation-induced cardiomyocyte senescence
Mitochondrial-Targeted SS-31 Attenuates the Doxorubicin-Induced Cardiomyoblast H9C2 Cell Senescence
Latest elamipretide research