SS-31
Phase 3aka Elamipretide, MTP-131
Mitochondria-targeting peptide in phase 3 for rare mitochondrial disease.
Mechanism
A tetrapeptide that binds cardiolipin in the inner mitochondrial membrane, basically trying to fix the wiring so the mitochondria make energy properly again. One of the few here in serious late-stage trials.
Regulatory & Safety Status
Investigational (Stealth BioTherapeutics), late-stage trials for rare mitochondrial conditions. Not approved.
Research
Mitochondrial-targeted SS-31 peptide attenuates radiation-induced cardiomyocyte senescence
Mitochondrial-Targeted SS-31 Attenuates the Doxorubicin-Induced Cardiomyoblast H9C2 Cell Senescence
Elamipretide: a mitochondria-targeting drug for Barth syndrome
Elamipretide (SS-31) and Nicotinamide Mononucleotide (NMN) Combination Therapy Targets TREM2 to Mitigate Post-ischemic Brain Injury in Mice
Latest elamipretide research