LL-37
Preclinicalaka Cathelicidin, CAP-18 fragment
Your body's own antibiotic. A broad antimicrobial and immune-signalling peptide.
Mechanism
The active fragment of human cathelicidin, a host-defense peptide that kills microbes directly and also runs inflammation, wound healing, and immune signalling. Double-edged though: too much of it is implicated in some inflammatory skin conditions.
Regulatory & Safety Status
Research stage, not approved as a therapeutic. Mostly a lab compound for now.
Research
A non-bactericidal antimicrobial peptide provides protective effect against bacterial sepsis via regulation of antimicrobial immunity and vascular endothelial functions
Immunomodulatory Effects of Poly-D,L-Lactic Acid on LL-37-Driven Rosacea-like Inflammation via Suppression of mTORC1 Signaling
RNA selectively modulates activity of virulent amyloid PSMα3 and host-defense LL-37 via phase separation and aggregation dynamics
Interfacial activity and membrane interaction of Duttaphrynus melanostictus cathelicidin
Latest LL-37 research