LL-37
Preclinicalaka Cathelicidin, CAP-18 fragment
Your body's own antibiotic. A broad antimicrobial and immune-signalling peptide.
Mechanism
The active fragment of human cathelicidin, a host-defense peptide that kills microbes directly and also runs inflammation, wound healing, and immune signalling. Double-edged though: too much of it is implicated in some inflammatory skin conditions.
Regulatory & Safety Status
Research stage, not approved as a therapeutic. Mostly a lab compound for now.
Research
Calcitonin gene-related peptide promotes mast cell-mediated neuroimmune inflammation through the CALCRL/RAMP1-JAK3-STAT1 axis in rosacea
Type I interferon in psoriasis: mechanisms and clinical implications
Emerging antimicrobial peptides in gastrointestinal disorders: Dual role in immunity and therapy
Plasma levels of antimicrobial peptide LL-37 as a biomarker of sleep quality in patients with obstructive sleep apnea: A clinical observational study
Latest LL-37 research