MOTS-c
Preclinicalaka Mitochondrial ORF of the 12S rRNA type-c
Mitochondrial peptide that acts like an exercise mimetic, at least in mice. A longevity-crowd favourite.
Mechanism
Coded inside your mitochondrial DNA. It seems to manage metabolism and insulin sensitivity, and in animals it does a lot of what exercise does. Promising, but the human work is barely started.
Regulatory & Safety Status
Early research, not approved, and the human data is very limited. Treat the longevity claims as hopeful, not proven.
Research
Synthetic Peptides in Pharmacy Compounding: Analysis of PCAC Recommendations and Industry Safety Standards
Mitokines as bioenergetic stress signals in cardiovascular disease: mitochondrial communication, endocrine adaptation, and translational implications
Correction: Reduced serum and skeletal muscle MOTS c levels in women with polycystic ovary syndrome are associated with mitochondrial dysfunction
AGEs-RAGE Axis and Mitochondrial-Derived Peptides in Advanced Chronic Kidney Disease: Interconnected Pathways Beyond Inflammation and Nutrition
MOTS-c metabolism and aging research
Latest MOTS-c research