MOTS-c
Preclinicalaka Mitochondrial ORF of the 12S rRNA type-c
Mitochondrial peptide that acts like an exercise mimetic, at least in mice. A longevity-crowd favourite.
Mechanism
Coded inside your mitochondrial DNA. It seems to manage metabolism and insulin sensitivity, and in animals it does a lot of what exercise does. Promising, but the human work is barely started.
Regulatory & Safety Status
Early research, not approved, and the human data is very limited. Treat the longevity claims as hopeful, not proven.
Research
The Mitochondrial-Derived Peptide MOTS-c Improves Bioenergetics in Aging-Associated Granulosa Cells and Oocytes
Mitochondria-Endoplasmic Reticulum Crosstalk in Pancreatic β-Cell Stress: A Driver of Diabetes
Mitochondrial-derived peptides in female reproduction: Emerging regulators of oocyte competence and novel therapeutic opportunities for infertility
MOTS-c mediates remote ischemic preconditioning-induced protection against lung ischemia-reperfusion injury via NRF2-dependent mitochondrial biogenesis
MOTS-c metabolism and aging research
Latest MOTS-c research